First recorded (as a demo) by Percy Mayfield (1960).
Hit versions by Ray Charles (US #1/R&B #1/UK #6/AUS #3 1961), The Stampeders (US #40/CAN #6 1975).
From the wiki: “‘Hit the Road Jack’ was written by R&B artist Percy Mayfield and was first recorded as an a cappella demo by Mayfield in 1960, before sending it to producer and Specialty Records owner Art Rupe. Rupe passed the song along to one of friends, Ray Charles. It became a worldwide hit after it was recorded by Charles – his sixth R&B #1 hit and second US #1 – with an arrangement featuring Raelettes’ vocalist Margie Hendrix, and would go on to also to win a Grammy award in 1962 for Best Rhythm and Blues Recording.”